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KMID : 0895820140240030001
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Journal of Oriental Rehabilitation Medicine
2014 Volume.24 No. 3 p.1 ~ p.9
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Acupuncture Effects of Fatty Mice Induced by High Fat Diet
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Woo Chang-Hoon
Lee Yong-Eun
Roh Seong-Soo
Kim Jae-Soo
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Abstract
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Objectives : The aim of this study was to investigate the effects of acupuncture on weight loss, food intake, lipid metabolism, adipogenesis.
Methods : Four week-old C57BL/6J mice acclimatized to the laboratory environment for 1 week were allocated into four groups of 6~8 mice each: normal diet group, high fat diet group, high fat diet group and treated with acupuncture at HT7, high fat diet group and treated with acupuncture at ST36 for 90days. High fat diet group was used to control group.
Results : 1) Body weight, food intake of the ST36, HT7 groups decreased compared with those of control group. ST36 group was more effective with body weight decrease, and HT7 group was more effective with food intake decrease. 2) NEFA, TG, TC, ALT, AST of the ST36, HT7 groups decreased compared with those of control group. ST36 group was more effective. 3) The expression of SREP-1c, SREBP-2 of the ST36 group decreased compared with those of control group. These decreased rates were statistically significant. SREBP-2 of the HT7 group decreased significantly compared to the control group. 4) LXR, FAS, SCD of the ST36 group decreased significantly compared with control group. 5) p-ACC, HMGCR of the ST36 group decreased significantly compared with those of control group. HMGCR of the HT7 group decreased significantly compared with control group.
Conclusions : These results suggest that ST36, HT7 acupuncture may be used prevent or treat the obesity induced by high fat diet.
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KEYWORD
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Acupuncture, ST36, HT7, Obesity, Lipid metabolism, Adipogenesis
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